ethyl 4-hydroxy-3-methoxycinnamate
ethyl 4-hydroxy-3-methoxycinnamate
CAS: 4046-02-0
Molecular Formula: C12H14O4
ethyl 4-hydroxy-3-methoxycinnamate - Names and Identifiers
| Name | ethyl 4-hydroxy-3-methoxycinnamate |
| Synonyms | AI3-23714 ETHYL FERULATE Ethyl Ferulate Ethyl ferulate UNII-5B8915UELW RARECHEM AL BI 0735 Ferulic Acid Ethylester FERULIC ACID ETHYL ESTER ethyl 4-hydroxy-3-methoxycinnamate ETHYL 4-HYDROXY-3-METHOXYCINNAMATE Ethyl 4'-hydroxy-3'-methoxycinnamate Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate 4-HYDROXY-3-METHOXYCINNAMIC ACID ETHYL ESTER ethyl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate ETHYL TRANS-3-(4'-HYDROXY-3'-METHOXYPHENYL)ACRYLATE ethyl (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, ethyl ester Ethyl ferulate~Ferulic acid ethyl ester~4-Hydroxy-3-methoxycinnamic acid ethyl ester |
| CAS | 4046-02-0 |
| EINECS | 223-745-5 |
| InChI | InChI=1/C12H14O4/c1-3-16-12(14)7-5-9-4-6-10(13)11(8-9)15-2/h4-8,13H,3H2,1-2H3/b7-5+ |
| InChIKey | ATJVZXXHKSYELS-FNORWQNLSA-N |
ethyl 4-hydroxy-3-methoxycinnamate - Physico-chemical Properties
| Molecular Formula | C12H14O4 |
| Molar Mass | 222.24 |
| Density | 1.0643 (rough estimate) |
| Melting Point | 63-65°C(lit.) |
| Boling Point | 164-166°C0.5mm Hg(lit.) |
| Flash Point | 132.5°C |
| Solubility | DMSO : ≥ 100 mg/mL (449.96 mM) |
| Vapor Presure | 2.17E-06mmHg at 25°C |
| Appearance | Colorless oily |
| Color | White to Off-White |
| BRN | 2696807 |
| pKa | 8.88±0.18(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Stability | Hygroscopic, Light Sensitive |
| Sensitive | Light Sensitive |
| Refractive Index | 1.4560 (estimate) |
| MDL | MFCD00009190 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Ligusticum chuanxiong halt rhizome. |
ethyl 4-hydroxy-3-methoxycinnamate - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29189900 |
| Hazard Note | Irritant |
ethyl 4-hydroxy-3-methoxycinnamate - Reference
| Reference Show more | 1. Cao Yanxia, Chen Jianbing et al. Screening and identification of a strain producing ferulic acid esterase and optimization of fermentation conditions [J]. Journal of Microbiology 2019 v.39(05):14-21. 2. [IF = 9.642] Ruonan Wang et al."Effective ferulic acid and xylo-oligosaccharides production by a novel multi-modular bifunctional xylase/feruloyl ester using." Bioresource Technol. 297:122487 |
ethyl 4-hydroxy-3-methoxycinnamate - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| introduction | ethyl ferulic acid is a ferulic acid ester derivative. compared with ferulic acid raw material, the fat solubility is greatly enhanced. It has the effects of anti-free radicals, anti-oxidation, promoting blood microcirculation, bodybuilding and skin protection in cosmetics. |
| function | 1. Antioxidation, scavenging oxygen free radicals, 2. Promoting blood microcirculation, 3. Sunscreen 4. Whitening and freckle removal have antagonistic effect on endothelin ET-1, competitively inhibit the combination of ET-1 and its receptor, and inhibit the proliferation of endothelin on melanocytes; 5. Bacteriostasis has a good inhibitory effect on Staphylococcus aureus, adding to cosmetics can reduce the use of preservatives. |
| Biological activity | Ethyl ferulate is a natural pro-ester derivative of ferulic acid isolated from anise, which can induce heme oxygenase 1 (HO-1), Protect rat neurons from oxidative stress. Ethyl ferulate can also protect neurons from systemic oxidative stress and neurotoxicity caused by β-amyloid peptide (1-42). |
| use | used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: the basic raw materials for the treatment of cardiovascular and cerebrovascular diseases and leukopenia. It is the basic raw material for the production of drugs for the treatment of cardiovascular and cerebrovascular diseases and leukopenia. |
Last Update：2024-04-09 19:05:12
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